Study Finds No Increased Risk of CVD Years After Infertility Therapies
12 Aug 2023 • The use of assisted reproductive technologies (ART) is not associated with an increased intermediate-term risk of CVD, according to the large multination Nordic ART study. While some nonsignificant trends were seen depending on the method of ART used, there were no differences in incident CVD risk at a median of 11 years in the overall cohort of women who used ART versus those who did not.
Many women with infertility have polycystic ovary syndrome (PCOS) or endometriosis, both of which have been linked to a higher risk of CVD, making it important to understand if the technologies themselves contribute further risk, Magnus and colleagues note. Their paper was published online August 9, 2023, in JAMA Cardiology.
The study included 2,496,441 individuals who gave birth in Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015), and Sweden (1985-2015). Overall, incident rates of any CVD over follow-up that ranged from 5 to 18 years across the studies was not significantly different between those who did and didn’t use any form of ART: 188 vs 152 events per 100,000 person-years.
Similarly, no differences were seen between women in the ART versus no ART groups in rates of ischemic heart disease, cerebrovascular disease, stroke, cardiomyopathy, heart failure, pulmonary embolism, or deep vein thrombosis. The ART group did, however, show a lower risk of MI compared with the non-ART group.
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