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Retinal Clarity: IRF Optical Density Ratio Predicts Visual Outcomes in nAMD

16 Apr 2025 • A new study sheds light on the prognostic potential of optical coherence tomography (OCT) biomarkers in neovascular age-related macular degeneration (nAMD).

Researchers found that higher optical density ratio (ODR) values of intraretinal fluid (IRF) were significantly associated with better preservation of best corrected visual acuity (deltaBCVA) over a 36-month period.

Both strict and flexible ODR measures of IRF showed a negative correlation with BCVA decline. Subretinal fluid (SRF) and pigment epithelial detachment (PED) ODR values bore no significant impact.

Source: Nature | Read Full Story

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