24 Jun 2024 • Metabolic surgery resulted in substantial and sustained weight loss compared to nonsurgical treatments in patients with obstructive sleep apnea (OSA) and obesity. It was also associated with a lower risk of major adverse cardiovascular events (MACE) and lower all-cause mortality.

• The study analyzed data from 13,657 patients with a mean age of 52.0 years. The median BMI was 41.0. There were 970 patients in the metabolic surgery group and 12,687 patients in the nonsurgical group. The median follow-up period was 5.3 years.

• At 10 years, the mean difference in body weight between the metabolic surgery group and the nonsurgical group was 26.6 kg. The 10-year cumulative incidence of MACE in the metabolic surgery group and nonsurgical group was 27.0% and 35.6%. The adjusted hazard ratio (HR) for MACE comparing metabolic surgery to nonsurgical treatment was 0.58. The 10-year cumulative incidence of all-cause mortality was 9.1% in the metabolic surgery group and 12.5% in the nonsurgical group. The adjusted HR for all-cause mortality comparing metabolic surgery to nonsurgical treatment was 0.63.

Source:JACC| Read full story