Prediabetes was linked to a higher risk of major clinical outcomes- such as atherosclerotic cardiovascular disease (ASCVD), heart failure, chronic kidney disease (CKD), and all-cause mortality - even without progressing to diabetes.

Over a follow-up period of up to **30 years**, prediabetes was associated with a modestly increased risk of these complications, and this risk remained significant after accounting for the development of diabetes. 

In fact, **85%** of the excess risk in individuals with prediabetes was attributable to factors independent of diabetes progression. 

*These findings suggest that prediabetes itself is a critical risk factor for long-term health issues, underscoring the need for early interventions to reduce complications, even before the onset of diabetes.*

Source: Diabetologia [Read full story](https://link.springer.com/article/10.1007/s00125-024-06315-0)