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New Antiplatelet Game Plan: Optimal Outcomes for ACS Patients Post-PCI

14 Oct 2024 • In a comprehensive analysis involving over 103,000 patients, researchers evaluated various antiplatelet strategies for acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).

  • In patients with ACS who undergo coronary stenting, dual‐antiplatelet therapy (DAPT) consisting of aspirin and a P2Y12 inhibitor (prasugrel, ticagrelor, or clopidogrel) for 12 months is the recommended reasonable approach to limit the risk of stent thrombosis and recurrent myocardial infarction
  • A new study compared the traditional 12-month dual-antiplatelet therapy (DAPT) of aspirin and clopidogrel to four alternative regimens.
  • Aspirin and ticagrelor for 3 months, followed by aspirin and clopidogrel for the remaining duration, can be considered the optimal strategy for treating post–percutaneous coronary intervention patients with acute coronary syndrome because of a significantly reduced risk of major adverse cardiovascular events without increasing the risk of bleeding.

This evolving strategy may reshape treatment protocols for post-PCI ACS patients, enhancing both safety and outcomes.

Source: JAHA | Read full story

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