A recent study on pyuria tests for diagnosing urinary tract infections (UTIs) in young children reveal that common methods may not always be reliable. 

Among 4188 children under 36 months undergoing bladder catheterization for suspected UTIs, the sensitivity of two widely used pyuria tests—leukocyte esterase on a dipstick and white blood cell (WBC) enumeration using digital imaging—were found to be 84% and 75%, respectively, in febrile children.

Despite these positive results, the study also discovered that approximately 20% of febrile children with a positive urine culture result had no detectable pyuria. 

*This finding raises concerns about the appropriateness of requiring pyuria for UTI diagnosis, suggesting that relying on pyuria alone could lead to missed diagnoses in young patients.*
                                                                                                                                                                                                         Source: American Academy of Pediatrics [Read full story](https://publications.aap.org/pediatrics/article-abstract/doi/10.1542/peds.2024-066600/199945/Accuracy-of-Screening-Tests-for-the-Diagnosis-of?redirectedFrom=fulltext?autologincheck=redirectedy.)