27 Sept 2023 • Previously, certain studies & randomised controlled trials (RCTs) have reported an association between calcium supplementation and increased risk of cardiovascular disease. A recent meta-analysis published in the journal Heart, Lung & Circulation aimed to determine the difference in associated risks of calcium supplementation with cardiovascular disease and stroke in RCTs.

• Researchers gathered relevant studies published up to August 6, 2021, from various databases.
• A total of 12 RCTs were included in the analysis, and the results showed that calcium supplementation was not associated with an increased risk of myocardial infarction, total stroke, heart failure admission, or all-cause/cardiovascular mortality.
• This conclusion remained consistent across different subgroups, including those receiving calcium alone or in combination with vitamin D, as well as varying follow-up durations and geographical regions.

The findings suggest that calcium supplementation does not appear to have a significant impact on these cardiovascular outcomes, although the authors recommend further studies to delve deeper into these associations.

Source: Heart, Lung & Circulation | Read full story