10 Aug 2023 • "This study investigated the relationship between proton pump inhibitor (PPI) usage and the risk of dementia. It analyzed data from the Atherosclerosis Risk in Communities (ARIC) Study, involving participants from 1987 to 2017. PPI use was assessed at various points, and participants were categorized based on current usage and cumulative usage before a specific baseline visit. The study found that using PPIs at the baseline visit did not significantly increase the risk of dementia during subsequent follow-up. However, individuals who had used PPIs for more than 4.4 cumulative years prior to the baseline visit had a 33% higher risk of developing dementia during follow-up. The study suggests that further research is needed to better understand the potential link between long-term PPI use and the development of dementia. The evidence from this study is classified as Class III, indicating an association between PPI use for over 4.4 years and a higher incidence of newly diagnosed dementia in individuals aged 45 years and older.

Source: Neurology | Read full story"