2 Aug 2024 • Among patients with heterozygous familial hypercholesterolaemia, researchers found that while LDL-cholesterol reductions were similar between sexes, males experienced a higher burden of ASCVD.

• Among 3,506 participants, men exhibited a significantly higher risk and earlier onset of ASCVD compared to women.
• Men had a median age at first ASCVD event of 50.6 years compared to 61.6 years for women.
• Males also had a 90% increased risk of ASCVD and 74% higher risk of cardiovascular death compared to females.
• Men also had a markedly lower major adverse cardiovascular event (MACE)-free survival time (71 years for men vs. 90 years for women).

These findings point to a critical need for tailored risk assessments and management strategies based on gender.

Source: The Lancet | Read full story