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U-Shaped Link Uncovered Between Liver Fat Index and Hypertension Risk

18 Apr 2025 • Analysis involving 17,501 adults reveals a compelling U-shaped relationship between the Hepatic Steatosis Index (HSI)—a non-invasive marker for liver fat—and hypertension.

Key Findings:

  • Over half of the participants (56.5%) had hypertension, with elevated HSI levels correlating strongly with increased hypertension risk.
  • Adjusted odds ratios surged to 2.29 and 4.03 in the third and fourth HSI quartiles, respectively.
  • Both high and unexpectedly low HSI levels were associated with higher blood pressure, suggesting that not just liver fat, but also underlying conditions like malnutrition or sarcopenia, may elevate risk.

Source: BMC Cardiovascular Disorders | Read Full Story

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