10 Apr 2025 • Tobacco smoking significantly raises the risk of aortic dissection. In a study of 500,000 people over 12.3 years, current smokers had over double the risk of aortic dissection (HR 2.48) vs never smokers, while former smokers showed no increased risk (HR 1.03).

Risk peaked at HR 2.94 for those smoking 10–19 cigarettes/day and was elevated with ≥30 pack-years (HR 1.66). Smoking cessation cut risk by up to 75%, with meta-analysis showing 22% risk reduction per decade (RR 0.78).

The findings highlight the lifesaving value of quitting smoking.

Source: Nature | Read Full Story