8 May 2025 • In the MUSA trial, women aged 21 and older with moderate to severe mixed urinary incontinence, unresponsive to prior therapies, experienced comparable symptom relief at 6 months with either intradetrusor onabotulinumtoxinA (100 U) or a midurethral sling.

Both treatments yielded similar improvements in total Urogenital Distress Inventory scores (UDI) (−66.8 points vs. −84.9). However, sling provided better improvement in stress symptoms (−45.2 vs −25.1).

These results indicate that both options can be effective, with treatment choice potentially guided by patient preference and clinical recommendations.

Source: JAMA | Read Full Story