Cardiac amyloidosis is increasingly recognized as an important and potentially treatable cause of heart failure, arrhythmias, increased wall thickness, and unexplained cardiac dysfunction. Yet its diagnosis is often delayed because its clinical presentation can mimic more common cardiovascular conditions.

This session will provide a practical, multimodality approach to recognizing, diagnosing, and managing cardiac amyloidosis. The discussion will explore clinical red flags, ECG and echocardiographic clues, cardiac MRI, nuclear scintigraphy, laboratory evaluation, and the differentiation of AL from ATTR amyloidosis. The session will also cover contemporary treatment strategies, including disease-modifying therapies and approaches to managing cardiac complications. Through clinical cases, clinicians will learn how to move from suspicion to definitive diagnosis and timely treatment.