I Rest My Case – Episode 01 brings to life a memorable clinical encounter where the challenges of managing drug-resistant bacterial infections demand careful clinical reasoning and timely therapeutic decisions. In conversation with host Dr. Tushar Shah, Dr. Neha Rastogi, Senior Consultant in Infectious diseases, revisits a case that stayed with her, exploring the diagnostic challenges, antimicrobial resistance, and the critical treatment decisions that shaped the patient's journey. The discussion will highlight the complexities of treating resistant Gram-negative infections and the role of aztreonam–avibactam (ATM-AVI) as a therapeutic option in appropriate clinical settings. Through real-world experience and expert perspectives, the episode offers practical antimicrobial stewardship insights and clinical pearls for healthcare professionals navigating increasingly complex resistant infections.