23 Mar 2024 • Androgenic anabolic steroids (AASs) are associated with cardiovascular-related and psychiatric morbidity and mortality, but the magnitude of these risks has been difficult to assess from small studies.

An 11-year observational study showed a roughly threefold higher risk for death in steroid users than in nonusers.

• During a mean follow-up of 11 years, 2.8% of AAS users and 1% of controls died, for a hazard ratio of 2.8 - a significant difference.
• In AAS users, HRs were 3.6 for unnatural deaths (i.e., accidents, violent crimes, or suicide) and 2.2 for natural deaths (e.g., cancer, cardiovascular-related deaths).
• Risk for death due to accidents and suicides is particularly notable, given known behavioral dysfunction with AAS use.

Source: NEJM J-Watch | Read full story