Initial Antibiotic Therapy For K. Pneumonia That is 'Inappropriate' Increases Patient Mortality

15 Sept 2023 • Researchers conducted a study on Klebsiella pneumoniae bloodstream infections and identified several key findings. Intra-abdominal infections were the most common source of Klebsiella pneumoniae infections, accounting for 34% of cases, while respiratory sources constituted only 6% but were associated with a higher in-hospital mortality rate.

The study also revealed that patients who received the "incorrect" first antibiotic, to which the bacteria were resistant, were more than five times as likely to die compared to those treated with a "correct" antibiotic.

The study underscores the critical importance of selecting the right initial antibiotic treatment, as it can have life-or-death consequences. Importantly, many cases where an incorrect antibiotic was administered had no prior indications from cultures that the patient would have a highly resistant bacterial infection.

Therefore, the researchers emphasize the need for better tools and more rapid identification methods to identify patients with resistant infections. This approach could help ensure that the right antibiotics are given promptly while avoiding unnecessary overuse of broad-spectrum antibiotics, which can contribute to antibiotic resistance. Ultimately, the study highlights the significance of both effective treatment and prevention strategies for Klebsiella pneumoniae infections.

Source: Healio | Read full story

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