10 Jan 2024 • The prevalence of RA differs based on sex, with the occurrence frequency in women being 4–5 times higher than that in men under the age of 50 years, and twice that in men between the ages of 60 and 70. Furthermore, the disease progression and disease activities are adverse in women compared with men.

The available epidemiological data on the role of hormonal and reproductive factors in the pathogenesis of RA are inconsistent and uncertain. In a recent study, researchers observed several hormonal and reproductive factors were associated with the risk of RA.

• Age at menarche >14 years, ≥4 children, early menopause, reproductive years <33, hysterectomy and oophorectomy, and the use of the exogenous hormone hormone replacement therapy were observed to be associated with a higher risk of RA.

Hormonal and reproductive factors should be considered in risk assessment and formulating management plans in female patients with RA.

Source: BMJ | Read full story