8 Aug 2024 • Doxycycline used as pre- and post-exposure prophylaxis (doxy-PrEP/PEP) significantly reduces bacterial sexually transmitted infections (STIs) among men who have sex with men (MSM) and transgender women (TGW).

• A meta-analysis, which included data from 1,766 participants, showed a 56% overall reduction in STI incidence with doxy-PrEP/PEP (RR=0.44).
• Specifically, doxy-PEP cut chlamydia cases by 81% (RR=0.19), syphilis by 77% (RR=0.23), and showed a 45% reduction in gonorrhea cases (RR=0.55), with no serious adverse effects reported.

The findings, supported by high-certainty evidence, underscore doxy-PEP's potential as a key preventive tool against STIs.

Source: IJID | Read full story