Game-Changer: Oral Therapy Non-Inferior to Intravenous for Low-Risk S. aureus Bloodstream Infections

18 Jan 2024 • Staphylococcus aureus bloodstream infection is commonly treated with at least 14 days of intravenous antimicrobials.

In a groundbreaking international trial, researchers have found that an early switch to oral antimicrobial therapy in low-risk Staphylococcus aureus bloodstream infections was non-inferior to the traditional intravenous approach in preventing complications related to the infection (including relapsing S. aureus bloodstream infection, deep-seated infection, and mortality attributable to infection) within 90 days.

However, it is necessary to carefully assess patients for signs and symptoms of complicated S aureus bloodstream infection at the time of presentation and thereafter before considering early oral switch therapy.

Source: The Lancet | Read full story

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