28 Dec 2023 • In a UK Biobank study, researchers explored the landscape of young-onset dementia (YOD), shedding light on both modifiable and nonmodifiable risk factors.

• Notably, lower formal education, socioeconomic status, and the presence of apolipoprotein ε4 allele were associated with a higher risk of YOD, increased handgrip strength showed a protective effect.
• Other significant contributors to YOD included alcohol use disorder, social isolation, vitamin D deficiency, elevated C-reactive protein levels, hearing impairment, and a history of stroke, diabetes, heart disease, and depression.

These findings underscore the potential for targeted interventions and lifestyle modifications to mitigate the risk of YOD, offering new avenues for dementia prevention in middle-aged adults.

Source: JAMA | Read full story