Oral Antibiotics Alone May Suffice as Viable Treatment for Uncomplicated Acute Appendicitis

19 Apr 2024 • The Appendicitis Acuta II trial compared the long-term outcomes of oral antibiotics alone versus combined intravenous (IV) and oral antibiotics for uncomplicated acute appendicitis.

Among 582 patients at the year 3 follow-up, treatment success rates were 63.4% with oral moxifloxacin and 65.2% with IV ertapenem plus oral levofloxacin and metronidazole, with no significant differences in adverse events, quality of life, or hospitalization length.

While statistical noninferiority wasn't achieved for oral antibiotics alone, the findings indicate their potential as an alternative treatment, with similar safety profiles and outcomes compared to the combination therapy.

Source: JAMA | Read full story

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