Nintedanib Takes the Lead: Slower FVC Decline in IPF Patients Compared to Pirfenidone

28 Nov 2023 • Antifibrotics are effective in slowing forced vital capacity (FVC) decline in idiopathic pulmonary fibrosis (IPF). However, whether antifibrotic type is differentially associated with FVC decline has remained inconclusive.

In a comparative analysis, researchers evaluated the impact of pirfenidone and nintedanib on the decline of FVC in individuals with idiopathic pulmonary fibrosis (IPF).

  • Patients with IPF who used nintedanib experienced a slower 12-month FVC decline than those on pirfenidone.
  • Importantly, no significant differences were observed in overall survival or non-elective respiratory hospitalization between the two groups.

Source: CHEST | Read full story

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