Testosterone Therapy's Surprising Downside for Bone Health: Higher Fracture Risk in Older Men

18 Jan 2024 • Testosterone treatment in men who have hypogonadism due to pituitary or testicular disease has been reported to improve many measures of their bone structure and quality.

Contrary to this belief, the TRAVERSE subtrial has revealed that testosterone treatment didn't offer protection against fractures in men with hypogonadism.

Compared with placebo, men who were on a testosterone gel actually had a significantly higher risk for fracture.

The researchers were quite surprised to find this, referencing how prior studies have demonstrated that testosterone increases bone structure and therefore might reduce the risk of fracture, in theory.

Source: NEJM | Read full story

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