Short DAPT May Be Especially Beneficial for Women at High Bleeding Risk

2 Dec 2023 • Women at high bleeding risk (HBR) do not seem to experience more ischemic or bleeding events than men and may especially benefit from a regimen of short dual antiplatelet therapy (DAPT) after PCI.

With an abbreviated. 1-month course of DAPT, this subanalysis showed that men in the MASTER DAPT trial reported a 1% increase of MACCE rates compared with those taking a standard DAPT regimen of at least 3 months, whereas women saw more than a 2% decrease in MACCE.

  • For the study published online in JAMA Cardiology, researchers included 4,579 HBR patients from the MASTER DAPT trial who were randomized at 1 month after PCI to abbreviated or standard DAPT.
  • Women on abbreviated DAPT saw a greater benefit regarding MACCE—defined as all-cause death, MI, or stroke- compared with men.
  • The rates of both ischemic and bleeding events were comparable between men and women, overall.

All results were maintained when looking only at ACS patients or those undergoing complex PCI.

Source: tctMD | Read full story

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