Targeting sdLDL-C: A Potential New Horizon in Stroke Prevention

16 Jan 2024 • Small dense low-density lipoprotein cholesterol (sdLDL-C) particles are more atherogenic than large and intermediate low-density lipoprotein cholesterol (LDL-C) subfractions.

  • In a recent study, higher levels of small dense LDL cholesterol (sdLDL-C) and the sdLDL-C/LDL-C ratio, but not LDL-C alone, were significantly linked to an increased risk of developing incident carotid plaques.
  • Participants in the upper tertile of sdLDL-C had a 2.48-fold higher risk of carotid plaques with vulnerable morphology. This association persisted even in individuals with normal LDL-C levels.
  • This suggests the potential of sdLDL-C as a therapeutic target for stroke prevention.

Source: Stroke | Read full story

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