11 Jul 2024 • A post hoc analysis involving 540 individuals with impaired glucose tolerance (IGT) revealed that individuals with IGT who stayed diabetes-free for at least 4 years (since IGT diagnosis) had significantly lower death risks.

• The study participants were initially diagnosed with IGT and underwent a 6-year lifestyle intervention trial. Over a 30-year follow-up period, outcomes such as death, cardiovascular events, and microvascular complications were monitored.

• The Cox analysis revealed that individuals who maintained non-diabetes status for at least 4 years after IGT diagnosis had significantly lower risks of all-cause death (HR: 0.74), cardiovascular events (HR: 0.63), and microvascular complications (HR: 0.62) compared to those who progressed to diabetes. Significant reductions in cardiovascular death were observed after 6 years (HR: 0.56). Adjustment for various factors including age, sex, BMI, blood pressure, blood glucose, and medications supported these findings.

Source:Plos Medicine| Read full story