7 Feb 2024 • In a study tracking women through the menopause transition, researchers discovered that a 10% reduced risk of diabetes was linked to a 5-unit increase in time-varying sex hormone binding globulin (SHBG), while testosterone (T) showed no significant association.

Quartiles reflecting stable to increasing rates of change in SHBG over the transition exhibited a decreased risk of diabetes compared to decreasing rates.

In conclusion, increasing levels of SHBG over the menopause transition were associated with a decreased risk of incident diabetes. Stable to increasing rates of change in SHBG were also independently associated with a decreased risk of diabetes compared with decreasing rates of change, suggesting SHBG may affect glucose through a mechanism beyond androgenicity.

Source: Diabetes Care | Read full story