23 Apr 2024 • In recent research, parenteral agents emerged as effective options for alleviating acute migraine pain, with combination therapy and monotherapy featuring neuroleptics or metoclopramide showing notable efficacy.

These approaches not only reduced pain scores significantly but also increased the proportion of patients reporting pain relief and being pain-free upon discharge from emergency departments.

However, heightened adverse events, particularly akathisia, were associated with most parenteral agents, underscoring the importance of a shared decision-making model to tailor treatment strategies to individual patient needs.

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