24 Sept 2024 • A new study comparing fasting plasma glucose (FPG), HbA1c, and the oral glucose tolerance test (OGTT) reveals that 2-hour post-load glucose (2hPG) is the most effective measure for detecting dysglycaemia and predicting cardiovascular events in patients with coronary artery disease.

Analyzing data from over 8,300 patients across Europe, researchers found that OGTT identified newly detected type 2 diabetes in 22.5% of cases, compared to just 4.2% with HbA1c.

The strongest predictors of cardiovascular risk were identified as a 2hPG of 9 mmol/L or greater (adjusted hazard ratio [aHR] 1.58), followed by an HbA1c of 5.9% or higher (aHR 1.48). Fasting plasma glucose (FPG) showed no predictive value

2hPG should be prioritized as the primary screening tool for dysglycemia in this patient population, given its critical role in predicting future cardiovascular risks.

Source: Lancet | Read full story