19 Dec 2023 • Treatment initiation with thiazide diuretics suggests a more substantial excess risk for hyponatremia, particularly during the first months of treatment.

A recent study involving over 180,000 individuals revealed that adults who utilized thiazide diuretics to manage hypertension were at a higher risk of developing hyponatremia within the first two years of initiating treatment compared to those who opted for nonthiazide agents.

Overall, older age and a greater number of comorbidities increased the cumulative hyponatremia in new users of thiazide-based hypertensives.

Clinicians should be aware of the potential development of hyponatremia and monitor and address the electrolyte abnormalities, the researchers concluded.

Source: Annals of Internal Medicine | Read full story