9 Mar 2024 • In adults undergoing total hip arthroplasty, a combination of paracetamol, ibuprofen, and dexamethasone had the lowest morphine consumption within 24 h following surgery and the most favourable adverse event profile.

• In the Non-opioid analgesic combinations following total hip arthroplasty (RECIPE) trial conducted at nine Danish hospitals, total hip arthroplasty (THA) patients receiving paracetamol, ibuprofen, and dexamethasone had significantly lower 24-hour morphine consumption post-surgery vs. paracetamol plus ibuprofen.

This combination demonstrated a reduction in both serious and non-serious adverse events, with lower incidences of nausea, vomiting, and dizziness.

Source: The Lancet | Read full story